Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
نویسندگان
چکیده
منابع مشابه
SURGICAL TREATMENT OF ULCERATIVE COLITIS
This is a preliminary report of 28 patients with ulcerative colitis who we surgically treated with "J" pouch endorectal pull-through operation from 1978 to 1996. All patients are continent with a median stool frequency of 4 times per day, no night soilage. low postoperative complications and one mortality due to pulmonary embolism.
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The aetiology of chronic non-specific ulcerative colitis remains obscure. All attempts to discover the cause of the disease by direct pathological experiment and research have failed. Therefore it seems reasonable to broaden the inquiry and to seek for similarities between this and other disease processes.
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BACKGROUND/AIMS Regional differences in the biology of the colonic epithelium may determine the extent of involvement by ulcerative colitis. Novel monoclonal antibodies (MAbs) were used in this study to investigate regional heterogeneity in the colonic mucosa. METHODS MAbs generated using a method of tolerisation against common antigens in the proximal colon and distal colon were used for imm...
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An 8 year old Brazilian girl had an infection, apparently confined to the large intestine, with Paracoccidioides brasiliensis. The symptoms were diarrhoea with fresh blood and mucus, severe malnutrition, and a spastic and ulcerated colon. She is making good progress on co-trimoxazole.
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Sera from 30 children, suffering from ulcerative colitis, were examined for the presence of antibodies capable of reacting with antigens of normal human tissue. It was possible to demonstrate that most of the sera contained a precipitating and hemagglutinating factor, reacting with a constituent of human colonic tissue. This constituent was obtained, within 1 hour after death, from colonic tiss...
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ژورنال
عنوان ژورنال: Cell
سال: 2019
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.06.029